Potent and broad anticancer activities of leaf extracts from Melia azedarach L. of the subtropical Okinawa islands
Identifieur interne : 000076 ( Main/Exploration ); précédent : 000075; suivant : 000077Potent and broad anticancer activities of leaf extracts from Melia azedarach L. of the subtropical Okinawa islands
Auteurs : Kuniaki Nerome [Japon] ; Taku Ito-Kureha [Japon] ; Tiziana Paganini [Japon] ; Takao Fukuda [Japon] ; Yasuhiro Igarashi [Japon] ; Hiroto Ashitomi [Japon] ; Shinya Ikematsu [Japon] ; Tadashi Yamamoto [Japon]Source :
- American Journal of Cancer Research [ 2156-6976 ] ; 2020.
Abstract
Plant extracts have been traditionally used for various therapeutic applications. By conducting an initial screening of several subtropical plants, in this study, we evaluated the anticancer activities of
Url:
PubMed: 32195029
PubMed Central: 7061759
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Plant extracts have been traditionally used for various therapeutic applications. By conducting an initial screening of several subtropical plants, in this study, we evaluated the anticancer activities of <italic>Melia azedarach L</italic>
. The extract from <italic>Melia azedarach L</italic>
. leaves (MLE) show high cytotoxic effects on cancer cells and <italic>in vivo</italic>
mouse and dog tumor models. During the initial screening, MLE showed strong antiproliferative activity against HT-29 colon, A549 lung, and MKN1 gastric cancer cells. In subsequent tests, using 39 human tumor cell lines, we confirmed the potent anticancer activities of MLE. The anticancer activity of MLE was also confirmed <italic>in vivo</italic>
. MLE markedly inhibited the growth of transplanted gastric MKN1 cancer xenografts in mice. To elucidate the mechanism underlying the anticancer effects of MLE, MLE-treated MKN1 cells were observed using an electron microscope; MLE treatment induced autophagy. Furthermore, western blot analysis of proteins in lysates of MLE-treated cells revealed induction of light chain 3 (LC3)-II autophagosomal proteins. Thus, MLE appeared to suppress MKN1 cell proliferation by inducing autophagy. In addition, in the mouse macrophage cell line J774A.1, MLE treatment induced TNF-α production, which might play a role in tumor growth suppression <italic>in vivo</italic>
. We also performed a preclinical evaluation of MLE treatment on dogs with various cancers in veterinary hospitals. Dogs with various types of cancers showed a mean recovery of 76% when treated with MLE. Finally, we tried to identify the active substances present in MLE. All the active fractions obtained by reverse-phase chromatography contained azedarachin B-related moieties, such as 3-deacetyl-12-hydroxy-amoorastatin, 12-hydroxy-amoorastatin, and 12-hydroxyamoorastaton. In conclusion, MLE contains substances with promising anticancer effects, suggesting their future use as safe and effective anticancer agents.</p>
</div>
</front>
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<affiliations><list><country><li>Japon</li>
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<tree><country name="Japon"><noRegion><name sortKey="Nerome, Kuniaki" sort="Nerome, Kuniaki" uniqKey="Nerome K" first="Kuniaki" last="Nerome">Kuniaki Nerome</name>
</noRegion>
<name sortKey="Ashitomi, Hiroto" sort="Ashitomi, Hiroto" uniqKey="Ashitomi H" first="Hiroto" last="Ashitomi">Hiroto Ashitomi</name>
<name sortKey="Fukuda, Takao" sort="Fukuda, Takao" uniqKey="Fukuda T" first="Takao" last="Fukuda">Takao Fukuda</name>
<name sortKey="Igarashi, Yasuhiro" sort="Igarashi, Yasuhiro" uniqKey="Igarashi Y" first="Yasuhiro" last="Igarashi">Yasuhiro Igarashi</name>
<name sortKey="Ikematsu, Shinya" sort="Ikematsu, Shinya" uniqKey="Ikematsu S" first="Shinya" last="Ikematsu">Shinya Ikematsu</name>
<name sortKey="Ito Kureha, Taku" sort="Ito Kureha, Taku" uniqKey="Ito Kureha T" first="Taku" last="Ito-Kureha">Taku Ito-Kureha</name>
<name sortKey="Paganini, Tiziana" sort="Paganini, Tiziana" uniqKey="Paganini T" first="Tiziana" last="Paganini">Tiziana Paganini</name>
<name sortKey="Yamamoto, Tadashi" sort="Yamamoto, Tadashi" uniqKey="Yamamoto T" first="Tadashi" last="Yamamoto">Tadashi Yamamoto</name>
</country>
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</record>
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